Comment 1 for bug 625368

You won't be able do draw precise shapes in this mode (bezier curves, circles, ellipses, spirals...) nor execute path operations without getting (slightly) distorted results. What about text objects/fonts?

Inkscape 0.48 includes the new extension 'pixelsnap' which allows to align rectangles and paths to pixel boundaries, to create sharp web and digital graphics.
See <http://code.google.com/p/pixelsnap/> for details and usage.

related bug reports:
Bug #561857 “[wish] new "boxmodel" for grid alignment (1pixel border issue)”
Bug #287943 “Add a Prepare for Bitmap Export screen (or equivalent)”
Bug #170392 “Advanced antialiasing control & font hinting”