Comment 5 for bug 226355

Ok I think I have found a fix in another bug post:
https://answers.launchpad.net/inkscape/+question/28776

Although this is a solution I hope that the next release of Inkscape can rectify this out of the box. Haven't tested stability or anything - just happy that it loads now!

Here's direct instructions from the above post:

open the Terminal application (its in Applications/Utilities)
1. "nano /Applications/Inkscape.app/Contents/Resources/script" (paste this into a terminal window without quotes and press ENTER)
2. then press CTRL+V (scrolls down a page)

3. change the code (use the arrows keys to get to the right part) from:

"""
else
        # Leopard onwards...

        # Warn the user about time-consuming generation of fontconfig caches.
        test -d ${HOME}/.fontconfig || exit 12
"""

to:

"""
else
        # Leopard onwards...

        # Warn the user about time-consuming generation of fontconfig caches.
        test -d ${HOME}/.fontconfig
"""
4. save changes - press CTRL+O and then ENTER to confirm
5. open Inkscape, go eat some snacks (it takes a few minutes for the first time - just like the popup window said)
6. Happiness

tGM