Comment 5 for bug 1591719

Note that while it will result in larger icons it will prevent Inkscape from using the native resolution of your display for on-canvas drawing and UI text, so you have to decide for yourself what's more important.

I did a comparison of both options in
https://inkscape.org/en/~eduard.braun/%E2%98%85inkscape_092x_dpiawarenon-dpiaware_200png

Good news is that the icon issue is fixed in Inkscape master (they are always the proper size and use full display resolution now), unfortunately we regressed on-canvas drawing, see bug #1285887.