Comment 2 for bug 1222520

Duplicate of
- Bug #819209 “Extensions do not work with Mac OS X Lion”
  <https://bugs.launchpad.net/inkscape/+bug/819209>

There is no need to install a custom Python version on your system (Inkscape's extensions won't work with Python 3 anyway), nor to install lxml (it is included in the application bundle).

The currently available Inkscape package (0.48.2) was built before Lion and Mountain Lion had been released, and the python-based extensions don't work out-of-the-box on these newer OS X versions (because Apple switched the system default Python version on Lion and Mountain Lion from 2.6 to 2.7).

Please read
<https://bugs.launchpad.net/inkscape/+bug/819209/comments/17>
and follow the link and instructions there for a rather easy fix (to insert a single into a shell script inside the application bundle).