Comment 9 for bug 1562501

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Christian Dannie Storgaard (cybolic) wrote : Re: After run vineyard, my wine app doesn't start anymore

This looks like it might be a problem with the executable you're trying to run not actually existing.
So, 3 questions:
1. Are you sure the someApp.exe file exists?
2. Have you tried running Wine with the full path to the file (e.g. wine ~/Downloads/someApp.exe)?
3. Does running a different Wine application work (e.g. wine 'C:/Windows/Notepad.exe')?

Vineyard doesn't actually change anything when you just run it, so I'm having a lot of trouble figuring out what might have happened to your default Wine prefix :/