Comment 88 for bug 1861936

Absolutely!

----------
My Raspberry Pi sits inside my home network, its config:

eth0:
IP: 192.168.200.11
GW: 192.168.200.1
IPv6: enabled (prefix delegation from ISP)
Metric: 300

wlan0:
IP: 192.168.209.11
GW: 192.168.209.1
IPv6: enabled (prefix delegation from ISP)
Metric: 400

wg0: flags=209<UP,POINTOPOINT,RUNNING,NOARP> mtu 1420
        inet 10.241.0.1 netmask 255.255.255.0 destination 10.241.0.1
        unspec 00-00-00-00-00-00-00-00-00-00-00-00-00-00-00-00 txqueuelen 1000 (UNSPEC)
        RX packets 37100 bytes 44690744 (44.6 MB)
        RX errors 0 dropped 0 overruns 0 frame 0
        TX packets 17505 bytes 4748492 (4.7 MB)
        TX errors 0 dropped 0 overruns 0 carrier 0 collisions 0

Wireguard config:
root@dns1:~# cat /etc/wireguard/wg0.conf
[Interface]
## This Desktop/client's private key ##
PrivateKey = <removed>

## Client ip address ##
Address = 10.241.0.1/24

[Peer]
## Ubuntu 20.04 server public key ##
PublicKey = <removed>

## set ACL ##
AllowedIPs = 10.241.0.0/24

## Your Ubuntu 20.04 LTS server's public IPv4/IPv6 address and port ##
Endpoint = <My VPS Public IPv4 IP>:51820

## Key connection alive ##
PersistentKeepalive = 15

ubuntu@dns1:~$ sudo wg
interface: wg0
  public key: <removed>
  private key: (hidden)
  listening port: 53514

peer: <removed>
  endpoint: <My VPS Public IPv4 IP>:51820
  allowed ips: 10.241.0.0/24
  latest handshake: 33 seconds ago
  transfer: 42.68 MiB received, 4.79 MiB sent
  persistent keepalive: every 15 seconds
ubuntu@dns1:~$

----------

My VPS hosted externally:
eth0: DHCP from VPS provider with IPv4/6(public IP, ie not NAT)

wg0: flags=209<UP,POINTOPOINT,RUNNING,NOARP> mtu 1420
        inet 10.241.0.3 netmask 255.255.255.0 destination 10.241.0.3
        unspec 00-00-00-00-00-00-00-00-00-00-00-00-00-00-00-00 txqueuelen 1000 (UNSPEC)
        RX packets 16739 bytes 4405736 (4.4 MB)
        RX errors 0 dropped 0 overruns 0 frame 0
        TX packets 36539 bytes 44736120 (44.7 MB)
        TX errors 0 dropped 0 overruns 0 carrier 0 collisions 0

root@m21:~# cat /etc/wireguard/wg0.conf
[Interface]
Address = 10.241.0.3/24
SaveConfig = true
ListenPort = 51820
FwMark = 0xca6c
PrivateKey = <removed>

[Peer]
PublicKey = <removed>
AllowedIPs = 10.241.0.1/32, 192.168.200.0/24, 192.168.209.0/24, 192.168.210.0/24, 192.168.211.0/24, 192.168.212.0/24
Endpoint = <My home public IPv4 IP>:33962
root@m21:~#

root@m21:~$ sudo wg
interface: wg0
  public key: <removed>
  private key: (hidden)
  listening port: 51820
  fwmark: 0xca6c

peer: <removed>
  endpoint: <My home public IPv4 IP>:53514
  allowed ips: 10.241.0.1/32, 192.168.200.0/24, 192.168.209.0/24, 192.168.210.0/24, 192.168.211.0/24, 192.168.212.0/24
  latest handshake: 1 minute, 36 seconds ago
  transfer: 5.33 MiB received, 42.91 MiB sent
root@m21:~$