Comment 76 for bug 1759014

I can confirm that on an up-to-date Ubuntu 22.04 use-dns doesn't work with the NetworkManager renderer. It does work with networkd.

network:
  ethernets:
    enp2s0:
      dhcp4: true
      dhcp4-overrides:
        use-dns: false
      nameservers:
        addresses: [9.9.9.9, 149.112.112.112]
        search: []
  renderer: NetworkManager
  version: 2

$ resolvectl status
Global
       Protocols: -LLMNR -mDNS -DNSOverTLS DNSSEC=no/unsupported
resolv.conf mode: uplink
     DNS Servers: 9.9.9.9

Link 2 (enp2s0)
Current Scopes: DNS
     Protocols: +DefaultRoute +LLMNR -mDNS -DNSOverTLS DNSSEC=no/unsupported
   DNS Servers: 9.9.9.9 149.112.112.112 192.168.0.1
    DNS Domain: Home

(With option "use-dns: false" 192.168.0.1 shouldn't be added to the list of DNS servers.)

With "renderer: networkd" it looks alright:

$ resolvectl status
Global
       Protocols: -LLMNR -mDNS -DNSOverTLS DNSSEC=no/unsupported
resolv.conf mode: uplink
     DNS Servers: 9.9.9.9

Link 2 (enp2s0)
Current Scopes: DNS
     Protocols: +DefaultRoute +LLMNR -mDNS -DNSOverTLS DNSSEC=no/unsupported
   DNS Servers: 9.9.9.9 149.112.112.112
    DNS Domain: Home