Comment 9 for bug 1992491

Still under the workarounds umbrella, instead of using:

DNS = <ip>

Try this under [Interface] instead:

PostUp = resolvectl dns %i <ip>

(if you already have a PostUp, just add another one)

That will configure the wireguard interface to use the specified <ip> as the DNS server for that interface. You can also add a domain search if you want:

PostUp = resolvectl dns %i <ip>; resolvectl domain %i \~domain

(replace "domain" with the actual domain suffix you want searched, but keep the "\~")