I install webkit2gtk 2.16.2-0ubuntu0.16.04.1 on Ubuntu GNOME 16.04 and webkit2gtk 2.16.2-0ubuntu0.16.10.1 on Ubuntu GNOME 16.10 and verified that epiphany, evolution and yelp all still work.
Also, I've been using webkit2gtk 2.16.2 on Ubuntu GNOME 17.04 for the past several days without a problem.
I install webkit2gtk 2.16.2- 0ubuntu0. 16.04.1 on Ubuntu GNOME 16.04 and webkit2gtk 2.16.2- 0ubuntu0. 16.10.1 on Ubuntu GNOME 16.10 and verified that epiphany, evolution and yelp all still work.
Also, I've been using webkit2gtk 2.16.2 on Ubuntu GNOME 17.04 for the past several days without a problem.