Comment 24 for bug 1829566

Well ... that configuration correction appears to have done the trick! I'm very sorry to have inadvertently put you through this for the sake an off-by-one-character invalid config. Re-reading the documentation I can now see where the confusion occurred when crafting the config originally, and I guess until now I was just unknowingly benefiting from a non-spec compliant edge-case in the previous version or some other chance alignment of stars. Cue the facepalm.

Here are the package versions and the updated config I've just tested successfully with:

ii network-manager 1.10.14-0ubuntu2
ii systemd 237-3ubuntu10.24

/etc/systemd/resolved.conf.d/local.org.com.conf
[Resolve]
Cache=no
DNS=127.0.0.54
Domains=~local.org.com

Huge thanks for sticking with this, it's really appreciated, and happy to provide any further information if you still feel there are questions here that need answering, but if not, maybe we can call this a wrap?