Comment 17 for bug 442748

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Daniel T Chen (crimsun) wrote : Re: Sound output is intermittent system-wide with nVidia MCP73 HDA

There are two issues here:

1) PA isn't running with realtime privileges. You can change this if you modify /etc/security/limits.conf, logout, and login. The web has instructions (google://ubuntu studio pam limits.conf realtime).

2) Wine, by default, doesn't have a native PA backend. Try Neil's PPA (again, use the web).