Comment 15 for bug 1715479

You're using the evdev driver and that usually means that the touchpad uses the synaptics driver. Both are effectively deprecated now, and gnome has dropped support for those so the gnome checkbox does nothing but look pretty.

Not sure why you're using evdev for the touchpad, do you have xorg-x11-drv-libinput installed? Check /etc/X11/xorg.conf.d for any leftover snippets, remove any mate or cinnamon packages if you have any.