Comment 15 for bug 1181666

I too am having this issue (I think).

The issue appears after I go to the activities "section", either by pressing the windows key or by clicking activities. The issue seems to happen when im running games that manipulate the mouse, the main examples are minecraft which locks the mouse somewhere while playing and Civ 5 which hides the mouse and uses a custom pointer. The games work fine until I go to the application overview and back. Most of the time, the mouse can still be moved but clicks stop doing anything in any windows and no hover effects are shown. The mouse works fine on the menu bar in gnome though. Sometimes the issue can be fixed by clicking a window a few times, if that doesn't work, alt tabing in and out of the game fixes it ocationally. If that still doesn't work, closing the game usually does. Looking into the issue further, it seems like clicking on a window sevral times and moving the mouse will almost always fix the issue.

Another way to solve the issue temporarily that I have found is to use the skype integration plugin and open a new skype window, then closing it. It's not related to skype since I have had the issue when not running it but it seems to be able to fix the issue. Looking into it some more, it seems like opening any window will work, for example using ctrl+alt+t.

Also, if no game which uses the mouse is running, opening the activities tab and closing it again without clicking on a window will require one click to gain focus and then one to actually click.