Comment 9 for bug 521523

I seem to have hit this also, although in my case it was causing desktop-couch to fail to startup:
└─(16:41:%)── ls ~/.cache/desktop-couch/log -lah ──(Mon,Feb22)─┘
total 84K
drwxr-xr-x 2 chris chris 4.0K 2010-02-04 10:20 .
drwx------ 3 chris chris 4.0K 2010-02-22 11:28 ..
-rw-r--r-- 1 chris chris 12K 2009-12-14 09:27 desktop-couch-replication.log
-rw-r--r-- 1 chris chris 6.5K 2009-11-04 22:10 desktop-couch-replication.log.2009-11-04
-rw-r--r-- 1 chris chris 38K 2010-02-22 11:36 desktop-couch-startup.log

└─(16:41:%)── less .cache/desktop-couch/log/desktop-couch-replication.log ──(Mon,Feb22)─┘
.cache/desktop-couch/log/desktop-couch-replication.log: Input/output error

I've stupidly deleted that file, though.