I'm still seeing this issue, it seems to be related to Chrome engaging with the file-picker because the unresponsiveness happens whenever I download, or upload a file. The file transfer goes through fine, but Chrome is immediately unresponsive to the mouse. Interestingly, it's restricted just to that window (and all of its tabs), other Chrome windows are just fine.
I'm still seeing this issue, it seems to be related to Chrome engaging with the file-picker because the unresponsiveness happens whenever I download, or upload a file. The file transfer goes through fine, but Chrome is immediately unresponsive to the mouse. Interestingly, it's restricted just to that window (and all of its tabs), other Chrome windows are just fine.