Comment 12 for bug 1586528

Exact same issue here, recently done dist-upgrade from 14.04 LTS to 16.04, I did not have this problem at all before. Not running on VM.

Linux server 4.4.0-75-generic #96-Ubuntu SMP Thu Apr 20 09:56:33 UTC 2017 x86_64 x86_64 x86_64 GNU/Linux

Using Wired ethernet, happens 2-3 times at least a week and need to reboot.

others have other NIC than Realtek ?
RTL8111/8168/8411 PCI Express Gigabit Ethernet Controller
driver=r8169 driverversion=2.3LK-NAPI firmware=rtl8168e-3_0.0.4 03/27/12

syslog not showing any hints to what happened other than already mentioned above.