Comment 26 for bug 76876

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F7205 2610539 54B8BD49D49D (krugerk) wrote : Re: /dev/dsp busy, but no program using it

I had something similar until I stumbled across this bug, the top of which there is mention of esd.

$ ps ax|grep esd
 8774 ? S 0:00 /usr/NX/bin/nxesd -tcp -nobeeps -port 6000 -bind 127.0.0.1
 9482 pts/1 R+ 0:00 grep esd

And sure enough, in my case nxesd (of the Nomachine program) was occupying the sound.
(I had the 'enable multimedia support' enabled for nx client connections to foreign servers.)