Comment 1 for bug 127015

Thanks for your bug report, more information is needed.

What brand and model is your keyboard and mouse?
How is your keyboard and mouse connected to your PC: PS/2, USB, USB wireless (Bluetooth), ...
For a USB keyboard or mouse include the output of the command lsusb on a terminal.
What mechanism does your mouse use: ball mouse, optical, trackball, ...
How many physical buttons and scrollwheels does you mouse have?

Try the following:
1. Direct after gnome login open a terminal and enter the following command:
  $ cp /var/log/Xorg.0.log ~/Xorg.0.log
  $ cp /var/log/dmesg ~/dmesg_boot
2. Wait until your mouse and keyboard stop working.
3. Open a terminal by pressing Ctrl-Alt-F1.
4. Enter the following commands:
  $ LANG=C
  $ cp /var/log/Xorg.0.log ~/Xorg.0.log_tmp
  $ diff -ns ~/Xorg.0.log ~/Xorg.0.log_tmp > ~/Xorg.0.log_diff-ns
  $ dmesg > ~/dmesg
  $ diff -ns ~/dmesg_boot ~/dmesg > ~/dmesg_diff-ns
5. Attach Xorg.0.log, Xorg.0.log_diff-ns, dmesg_boot and dmesg_diff-ns to this bug report.