Comment 1 for bug 1803895

I will add a
Settings.WheelNatural

with a default of True (WHEEL_UP moves content towards top and reveals content at the bottom == Mac-Natural)

Setting it to False will reverse it and should meet your requirement.
You have to add it at the start of every main script, whose run needs it.

Be aware, that currently still the most Settings keep their value in the IDE until changed again - there is no complete reset to defaults neither at script start nor at the end (open request).