Comment 6 for bug 238658

So, I don't know how to fix this. setuptools is not APT, and knows nothing about C libraries. I don't think it is likely or reasonable to expect that the pyopenssl authors will put a full copy of !OpenSSL in their source tree.

Personally, I think this is going to be a "root dependency": something that isn't going to get auto-installed, and we should just document the requirement and oblige the developer to get it installed somehow.