Comment 16 for bug 1282294

Happened to me during casual dist-upgrade on Ubuntu Gnome 14.04:
---
Processing triggers for gnome-icon-theme (3.10.0-0ubuntu2) ...

(gtk-update-icon-cache-3.0:9274): GdkPixbuf-WARNING **: Cannot open pixbuf loader module file '/usr/lib/x86_64-linux-gnu/gdk-pixbuf-2.0/2.10.0/loaders.cache': No such file or directory

This likely means that your installation is broken.
Try running the command
  gdk-pixbuf-query-loaders > /usr/lib/x86_64-linux-gnu/gdk-pixbuf-2.0/2.10.0/loaders.cache
to make things work again for the time being.
---