CVE 2016-8743
Apache HTTP Server, in all releases prior to 2.2.32 and 2.4.25, was liberal in the whitespace accepted from requests and sent in response lines and headers. Accepting these different behaviors represented a security concern when httpd participates in any chain of proxies or interacts with back-end application servers, either through mod_proxy or using conventional CGI mechanisms, and may result in request smuggling, response splitting and cache pollution.
See the 
CVE page on Mitre.org
for more details.
