Comment 32 for bug 565342

One way this could get fixed is if wineserver was overhauled a little to delay loading the HKCU registry key until each client connects. The HKCU key would be attached to each connection instead of being global. As the wine client connects it would first announce the username/sid and then wineserver could load the user.reg file from the users .wine folder.
This means that wineserver would have to run as root to load other users files like a system service.
wineserver -s, --service multi-user service