This affected me on 12.04 32bit, after upgrading to 12.10 and more recently 13.04 the issue was gone, however I upgraded my hard drive to an SSD so re-installed 13.04 amd64 this time and the issue is back.
Within 1-2 days after reboot NM applet becomes unresponsive, I can't select wireless networks, nor change my wired network settings.
This affected me on 12.04 32bit, after upgrading to 12.10 and more recently 13.04 the issue was gone, however I upgraded my hard drive to an SSD so re-installed 13.04 amd64 this time and the issue is back.
Within 1-2 days after reboot NM applet becomes unresponsive, I can't select wireless networks, nor change my wired network settings.