FTR: this guest XML (not out of gnome-boxes) works on the very same Host system.
This runs qxl + gl=yes as well and does not fail.
We need to find what the difference is between those is as well.

<domain type='kvm'>
  <name>ubuntu18.04</name>
  <uuid>2f6bde7c-1d3d-498a-b96c-8920f165fa4c</uuid>
  <metadata>
    <libosinfo:libosinfo xmlns:libosinfo="http://libosinfo.org/xmlns/libvirt/domain/1.0">
      <libosinfo:os id="http://ubuntu.com/ubuntu/18.04"/>
    </libosinfo:libosinfo>
  </metadata>
  <memory unit='KiB'>2097152</memory>
  <currentMemory unit='KiB'>2097152</currentMemory>
  <vcpu placement='static'>2</vcpu>
  <os>
    <type arch='x86_64' machine='pc-q35-3.1'>hvm</type>
    <boot dev='hd'/>
  </os>
  <features>
    <acpi/>
    <apic/>
    <vmport state='off'/>
  </features>
  <cpu mode='host-model' check='partial'>
    <model fallback='allow'/>
  </cpu>
  <clock offset='utc'>
    <timer name='rtc' tickpolicy='catchup'/>
    <timer name='pit' tickpolicy='delay'/>
    <timer name='hpet' present='no'/>
  </clock>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>destroy</on_crash>
  <pm>
    <suspend-to-mem enabled='no'/>
    <suspend-to-disk enabled='no'/>
  </pm>
  <devices>
    <emulator>/usr/bin/qemu-system-x86_64</emulator>
    <disk type='file' device='disk'>
      <driver name='qemu' type='qcow2'/>
      <source file='/var/lib/libvirt/images/ubuntu18.04.qcow2'/>
      <target dev='vda' bus='virtio'/>
      <address type='pci' domain='0x0000' bus='0x03' slot='0x00' function='0x0'/>
    </disk>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <target dev='sda' bus='sata'/>
      <readonly/>
      <address type='drive' controller='0' bus='0' target='0' unit='0'/>
    </disk>
    <controller type='usb' index='0' model='ich9-ehci1'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1d' function='0x7'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci1'>
      <master startport='0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1d' function='0x0' multifunction='on'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci2'>
      <master startport='2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1d' function='0x1'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci3'>
      <master startport='4'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1d' function='0x2'/>
    </controller>
    <controller type='sata' index='0'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1f' function='0x2'/>
    </controller>
    <controller type='pci' index='0' model='pcie-root'/>
    <controller type='pci' index='1' model='pcie-root-port'>
      <model name='pcie-root-port'/>
      <target chassis='1' port='0x10'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0' multifunction='on'/>
    </controller>
    <controller type='pci' index='2' model='pcie-root-port'>
      <model name='pcie-root-port'/>
      <target chassis='2' port='0x11'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x1'/>
    </controller>
    <controller type='pci' index='3' model='pcie-root-port'>
      <model name='pcie-root-port'/>
      <target chassis='3' port='0x12'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x2'/>
    </controller>
    <controller type='pci' index='4' model='pcie-root-port'>
      <model name='pcie-root-port'/>
      <target chassis='4' port='0x13'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x3'/>
    </controller>
    <controller type='pci' index='5' model='pcie-root-port'>
      <model name='pcie-root-port'/>
      <target chassis='5' port='0x14'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x4'/>
    </controller>
    <controller type='pci' index='6' model='pcie-root-port'>
      <model name='pcie-root-port'/>
      <target chassis='6' port='0x15'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x5'/>
    </controller>
    <controller type='virtio-serial' index='0'>
      <address type='pci' domain='0x0000' bus='0x02' slot='0x00' function='0x0'/>
    </controller>
    <interface type='network'>
      <mac address='52:54:00:8c:31:fc'/>
      <source network='default'/>
      <model type='virtio'/>
      <address type='pci' domain='0x0000' bus='0x01' slot='0x00' function='0x0'/>
    </interface>
    <serial type='pty'>
      <target type='isa-serial' port='0'>
        <model name='isa-serial'/>
      </target>
    </serial>
    <console type='pty'>
      <target type='serial' port='0'/>
    </console>
    <channel type='unix'>
      <target type='virtio' name='org.qemu.guest_agent.0'/>
      <address type='virtio-serial' controller='0' bus='0' port='1'/>
    </channel>
    <channel type='spicevmc'>
      <target type='virtio' name='com.redhat.spice.0'/>
      <address type='virtio-serial' controller='0' bus='0' port='2'/>
    </channel>
    <input type='tablet' bus='usb'>
      <address type='usb' bus='0' port='1'/>
    </input>
    <input type='mouse' bus='ps2'/>
    <input type='keyboard' bus='ps2'/>
    <graphics type='spice'>
      <listen type='none'/>
      <image compression='off'/>
      <gl enable='yes'/>
    </graphics>
    <sound model='ich9'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1b' function='0x0'/>
    </sound>
    <video>
      <model type='qxl' ram='65536' vram='65536' vgamem='16384' heads='1' primary='yes'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x0'/>
    </video>
    <redirdev bus='usb' type='spicevmc'>
      <address type='usb' bus='0' port='2'/>
    </redirdev>
    <redirdev bus='usb' type='spicevmc'>
      <address type='usb' bus='0' port='3'/>
    </redirdev>
    <memballoon model='virtio'>
      <address type='pci' domain='0x0000' bus='0x04' slot='0x00' function='0x0'/>
    </memballoon>
    <rng model='virtio'>
      <backend model='random'>/dev/urandom</backend>
      <address type='pci' domain='0x0000' bus='0x05' slot='0x00' function='0x0'/>
    </rng>
  </devices>
</domain>

P.S. I'm on a trip next week so further response might take a while, sorry