Do you dual boot into Windows?
This seems to be the cause of the problem for myself, at least - in Ubuntu 64bit (12.04.2LTS Precise and 12.10 Quantal), dual booting from Windows 7.
After having this same bug I have found a way to reproduce the problem:
-Boot into Windows, turn headset on, restart into Ubuntu and try adjust the volume with the volume wheel
In this case it almost always will cause similar GUI unresponsiveness to what you described.
Possible workaround:
-When in Windows or before booting into Ubuntu, turn off the headset -> boot into Ubuntu -> turn on then headset
Note: Restarting Ubuntu once the headphones were previously turned on in Ubuntu does not cause it to become unresponsive (only when restarting from windows). Disconnecting the wireless receiver does not count as turning off the headset
Do you dual boot into Windows?
This seems to be the cause of the problem for myself, at least - in Ubuntu 64bit (12.04.2LTS Precise and 12.10 Quantal), dual booting from Windows 7.
After having this same bug I have found a way to reproduce the problem:
-Boot into Windows, turn headset on, restart into Ubuntu and try adjust the volume with the volume wheel
In this case it almost always will cause similar GUI unresponsiveness to what you described.
Possible workaround:
-When in Windows or before booting into Ubuntu, turn off the headset -> boot into Ubuntu -> turn on then headset
Note: Restarting Ubuntu once the headphones were previously turned on in Ubuntu does not cause it to become unresponsive (only when restarting from windows). Disconnecting the wireless receiver does not count as turning off the headset