Same error for 5.8.0-25-generic.

$ sudo apt remove linux-headers-5.9.1-050901-generic linux-modules-5.9.1-050901-generic
[sudo] password for darxus: 
Reading package lists... Done
Building dependency tree       
Reading state information... Done
The following packages will be REMOVED:
  linux-headers-5.9.1-050901-generic linux-modules-5.9.1-050901-generic
0 upgraded, 0 newly installed, 2 to remove and 3 not upgraded.
3 not fully installed or removed.
After this operation, 288 MB disk space will be freed.
Do you want to continue? [Y/n] 
(Reading database ... 618879 files and directories currently installed.)
Removing linux-headers-5.9.1-050901-generic (5.9.1-050901.202010170731) ...
Removing linux-modules-5.9.1-050901-generic (5.9.1-050901.202010170731) ...
Setting up virtualbox-dkms (6.1.10-dfsg-1~ubuntu1.20.04.1) ...
Removing old virtualbox-6.1.10 DKMS files...

-------- Uninstall Beginning --------
Module:  virtualbox
Version: 6.1.10
Kernel:  5.4.0-54-generic (x86_64)
-------------------------------------

Status: Before uninstall, this module version was ACTIVE on this kernel.

vboxdrv.ko:
 - Uninstallation
   - Deleting from: /lib/modules/5.4.0-54-generic/updates/dkms/
 - Original module
   - No original module was found for this module on this kernel.
   - Use the dkms install command to reinstall any previous module version.


vboxnetadp.ko:
 - Uninstallation
   - Deleting from: /lib/modules/5.4.0-54-generic/updates/dkms/
 - Original module
   - No original module was found for this module on this kernel.
   - Use the dkms install command to reinstall any previous module version.


vboxnetflt.ko:
 - Uninstallation
   - Deleting from: /lib/modules/5.4.0-54-generic/updates/dkms/
 - Original module
   - No original module was found for this module on this kernel.
   - Use the dkms install command to reinstall any previous module version.

depmod...

DKMS: uninstall completed.

------------------------------
Deleting module version: 6.1.10
completely from the DKMS tree.
------------------------------
Done.
Loading new virtualbox-6.1.10 DKMS files...
Building for 5.4.0-54-generic 5.8.0-25-generic
Building initial module for 5.4.0-54-generic
Done.

vboxdrv.ko:
Running module version sanity check.
 - Original module
   - No original module exists within this kernel
 - Installation
   - Installing to /lib/modules/5.4.0-54-generic/updates/dkms/

vboxnetadp.ko:
Running module version sanity check.
 - Original module
   - No original module exists within this kernel
 - Installation
   - Installing to /lib/modules/5.4.0-54-generic/updates/dkms/

vboxnetflt.ko:
Running module version sanity check.
 - Original module
   - No original module exists within this kernel
 - Installation
   - Installing to /lib/modules/5.4.0-54-generic/updates/dkms/

depmod...

DKMS: install completed.
Building initial module for 5.8.0-25-generic
ERROR (dkms apport): kernel package linux-headers-5.8.0-25-generic is not supported
Error! Bad return status for module build on kernel: 5.8.0-25-generic (x86_64)
Consult /var/lib/dkms/virtualbox/6.1.10/build/make.log for more information.
dpkg: error processing package virtualbox-dkms (--configure):
 installed virtualbox-dkms package post-installation script subprocess returned error exit status 10
dpkg: dependency problems prevent configuration of virtualbox:
 virtualbox depends on virtualbox-dkms (>= 6.1.10-dfsg-1~ubuntu1.20.04.1) | virtualbox-source (>= 6.1.10-dfsg-1~ubuntu1.20.04.1) | virtualbox-modules; however:
  Package virtualbox-dkms is not configured yet.
  Package virtualbox-source is not installed.
  Package virtualbox-modules is not installed.
  Package virtualbox-dkms which provides virtualbox-modules is not configured yet.

dpkg: error processing package virtualbox (--configure):
 dependency problems - leaving unconfigured
dpkg: dependency problems prevent configuration of virtualbox-qt:
 virtualbox-qt depends on virtualbox (= 6.1.10-dfsg-1~ubuntu1.20.04.1); however:
  Package virtualbox is not configured yet.

dpkg: error processing package virtualbox-qt (--configure):
 dependency problems - leaving unconfigured
No apport report written because the error message indicates its a followup error from a previous failure.
                                                                                                          No apport report written because the error message indicates its a followup error from a previous failure
.
 Errors were encountered while processing:
 virtualbox-dkms
 virtualbox
 virtualbox-qt
E: Sub-process /usr/bin/dpkg returned an error code (1)
$