Comment 22 for bug 1624320

Here is my use case experience, after running a clean install of Kubuntu 17.10.

Initially everything was perfect, and for at least 10 days my machine booted perfectly fine and DNS working without issue.

However, after installing virt manage Virtual Machine Manager, like so

sudo apt-get install qemu-system qemu-kvm virt-manager wireshark

I configured some additional Virbr networks ( see below ) The following day after a reboot, I had no DNS resolution, I hacked /etc/resolv.conf to add a nameserver. All good until reboot, and then back to square one.

Once I discovered this bug things became clearer, and I have applied fix at post #8 above

I figure that my use of virt-manager might be an interesting edge case that break things with systemd-resolve. Below is the output from status, which highlights the issue, there are no DNS servers listed.

Hope this info is useful

ricktimmis@ricktimmis-Latitude-E6430:~$ systemd-resolve --status
Global
          DNSSEC NTA: 10.in-addr.arpa
                      16.172.in-addr.arpa
                      168.192.in-addr.arpa
                      17.172.in-addr.arpa
                      18.172.in-addr.arpa
                      19.172.in-addr.arpa
                      20.172.in-addr.arpa
                      21.172.in-addr.arpa
                      22.172.in-addr.arpa
                      23.172.in-addr.arpa
                      24.172.in-addr.arpa
                      25.172.in-addr.arpa
                      26.172.in-addr.arpa
                      27.172.in-addr.arpa
                      28.172.in-addr.arpa
                      29.172.in-addr.arpa
                      30.172.in-addr.arpa
                      31.172.in-addr.arpa
                      corp
                      d.f.ip6.arpa
                      home
                      internal
                      intranet
                      lan
                      local
                      private
                      test

Link 23 (vnet1)
      Current Scopes: LLMNR/IPv6
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 17 (vnet0)
      Current Scopes: LLMNR/IPv6
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 15 (vnet5)
      Current Scopes: none
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 14 (vnet4)
      Current Scopes: none
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 13 (vnet3)
      Current Scopes: LLMNR/IPv6
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 9 (virbr0-nic)
      Current Scopes: none
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 8 (virbr0)
      Current Scopes: LLMNR/IPv4
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 7 (virbr1-nic)
      Current Scopes: none
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 6 (virbr1)
      Current Scopes: LLMNR/IPv4
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 5 (br0)
      Current Scopes: LLMNR/IPv4 LLMNR/IPv6
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 4 (eth1)
      Current Scopes: none
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 3 (wlan0)
      Current Scopes: none
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no

Link 2 (eth0)
      Current Scopes: LLMNR/IPv4 LLMNR/IPv6
       LLMNR setting: yes
MulticastDNS setting: no
      DNSSEC setting: no
    DNSSEC supported: no