You can very easily remove a GNOME runtime snap without any warning of the consequences of this action.
i.e.
$ snap remove gnome-3-28-1804
$ gnome-calculator
/snap/gnome-calculator/544/snap/command-chain/desktop-launch: line 11: /snap/gnome-calculator/544/gnome-platform/usr/lib/x86_64-linux-gnu/libgtk-3-0/gtk-query-immodules-3.0: No such file or directory
ERROR: /snap/gnome-calculator/544/gnome-platform/usr/lib/x86_64-linux-gnu/libgtk-3-0/gtk-query-immodules-3.0 exited abnormally with status 127
And if you try and correct this mistake:
$ snap install gnome-3-28-1804
$ gnome-calculator
/home/bob/snap/gnome-calculator/common/.cache/gio-modules/libgiognomeproxy.so: cannot open shared object file: No such file or directory
Failed to load module: /home/bob/snap/gnome-calculator/common/.cache/gio-modules/libgiognomeproxy.so
/home/bob/snap/gnome-calculator/common/.cache/gio-modules/libdconfsettings.so: cannot open shared object file: No such file or directory
Failed to load module: /home/bob/snap/gnome-calculator/common/.cache/gio-modules/libdconfsettings.so
/home/bob/snap/gnome-calculator/common/.cache/gio-modules/libgiolibproxy.so: cannot open shared object file: No such file or directory
Failed to load module: /home/bob/snap/gnome-calculator/common/.cache/gio-modules/libgiolibproxy.so
/home/bob/snap/gnome-calculator/common/.cache/gio-modules/libgiognutls.so: cannot open shared object file: No such file or directory
Failed to load module: /home/bob/snap/gnome-calculator/common/.cache/gio-modules/libgiognutls.so
(gnome-calculator:205254): GdkPixbuf-WARNING **: 13:33:47.404: Cannot open pixbuf loader module file '/home/bob/snap/gnome-calculator/common/.cache/gdk-pixbuf-loaders.cache': No such file or directory
This likely means that your installation is broken.
Try running the command
gdk-pixbuf-query-loaders > /home/bob/snap/gnome-calculator/common/.cache/gdk-pixbuf-loaders.cache
to make things work again for the time being.
The same issue occurs in other clients, e.g. GNOME Software.