I have exactly the same problem and the same built-in USB device, so I can confirm its not an isolated instance. The device driver (gspca_m5602) being loaded/unloaded makes no difference. Suspend worked in karmic. lsusb -v Bus 001 Device 002: ID 0402:5602 ALi Corp. Video Camera Controller Device Descriptor: bLength 18 bDescriptorType 1 bcdUSB 2.00 bDeviceClass 0 (Defined at Interface level) bDeviceSubClass 0 bDeviceProtocol 0 bMaxPacketSize0 64 idVendor 0x0402 ALi Corp. idProduct 0x5602 Video Camera Controller bcdDevice 1.00 iManufacturer 0 iProduct 1 USB2.0 Camera iSerial 0 bNumConfigurations 1 Configuration Descriptor: bLength 9 bDescriptorType 2 wTotalLength 101 bNumInterfaces 1 bConfigurationValue 1 iConfiguration 0 bmAttributes 0xa0 (Bus Powered) Remote Wakeup MaxPower 500mA Interface Descriptor: bLength 9 bDescriptorType 4 bInterfaceNumber 0 bAlternateSetting 0 bNumEndpoints 2 bInterfaceClass 255 Vendor Specific Class bInterfaceSubClass 255 Vendor Specific Subclass bInterfaceProtocol 255 Vendor Specific Protocol iInterface 0 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x81 EP 1 IN bmAttributes 1 Transfer Type Isochronous Synch Type None Usage Type Data wMaxPacketSize 0x0000 1x 0 bytes bInterval 1 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x82 EP 2 IN bmAttributes 3 Transfer Type Interrupt Synch Type None Usage Type Data wMaxPacketSize 0x0000 1x 0 bytes bInterval 4 Interface Descriptor: bLength 9 bDescriptorType 4 bInterfaceNumber 0 bAlternateSetting 1 bNumEndpoints 2 bInterfaceClass 255 Vendor Specific Class bInterfaceSubClass 255 Vendor Specific Subclass bInterfaceProtocol 255 Vendor Specific Protocol iInterface 0 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x81 EP 1 IN bmAttributes 1 Transfer Type Isochronous Synch Type None Usage Type Data wMaxPacketSize 0x1400 3x 1024 bytes bInterval 1 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x82 EP 2 IN bmAttributes 3 Transfer Type Interrupt Synch Type None Usage Type Data wMaxPacketSize 0x0010 1x 16 bytes bInterval 4 Interface Descriptor: bLength 9 bDescriptorType 4 bInterfaceNumber 0 bAlternateSetting 2 bNumEndpoints 2 bInterfaceClass 255 Vendor Specific Class bInterfaceSubClass 255 Vendor Specific Subclass bInterfaceProtocol 255 Vendor Specific Protocol iInterface 0 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x81 EP 1 IN bmAttributes 1 Transfer Type Isochronous Synch Type None Usage Type Data wMaxPacketSize 0x1380 3x 896 bytes bInterval 1 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x82 EP 2 IN bmAttributes 3 Transfer Type Interrupt Synch Type None Usage Type Data wMaxPacketSize 0x0010 1x 16 bytes bInterval 4 Interface Descriptor: bLength 9 bDescriptorType 4 bInterfaceNumber 0 bAlternateSetting 3 bNumEndpoints 2 bInterfaceClass 255 Vendor Specific Class bInterfaceSubClass 255 Vendor Specific Subclass bInterfaceProtocol 255 Vendor Specific Protocol iInterface 0 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x81 EP 1 IN bmAttributes 1 Transfer Type Isochronous Synch Type None Usage Type Data wMaxPacketSize 0x1300 3x 768 bytes bInterval 1 Endpoint Descriptor: bLength 7 bDescriptorType 5 bEndpointAddress 0x82 EP 2 IN bmAttributes 3 Transfer Type Interrupt Synch Type None Usage Type Data wMaxPacketSize 0x0010 1x 16 bytes bInterval 4 Device Qualifier (for other device speed): bLength 10 bDescriptorType 6 bcdUSB 2.00 bDeviceClass 0 (Defined at Interface level) bDeviceSubClass 0 bDeviceProtocol 0 bMaxPacketSize0 64 bNumConfigurations 1 Device Status: 0x0000 (Bus Powered)