Bug confirmed. Neither rmmod ehci_hcd nor irqpoll are acceptable solutions because ehci_hcd disables USB 2.0 support and irqpoll is ridden with a lot of bugs for users (doing a quick irqpoll search on the internet reveals this). Also, adding kernel options such as irqpoll for all users should not acceptable. There must be another fix for this. One small tidbit that may help: using almost identical hardware, with identical USB controllers, the computer with two USB ports has problems, the one with only one USB ports does not. OUTPUT OF 1 USB PORT COMPUTER (w/o problems): $ lsusb Bus 004 Device 001: ID 0000:0000 Bus 002 Device 001: ID 0000:0000 Bus 001 Device 001: ID 0000:0000 Bus 003 Device 001: ID 0000:0000 $ lspci 00:1d.0 USB Controller: Intel Corporation 82801DB/DBL/DBM (ICH4/ICH4-L/ICH4-M) USB UHCI Controller #1 (rev 01) 00:1d.1 USB Controller: Intel Corporation 82801DB/DBL/DBM (ICH4/ICH4-L/ICH4-M) USB UHCI Controller #2 (rev 01) 00:1d.2 USB Controller: Intel Corporation 82801DB/DBL/DBM (ICH4/ICH4-L/ICH4-M) USB UHCI Controller #3 (rev 01) 00:1d.7 USB Controller: Intel Corporation 82801DB/DBM (ICH4/ICH4-M) USB2 EHCI Controller (rev 01) $ cat /proc/bus/usb/devices T: Bus=04 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=12 MxCh= 2 B: Alloc= 0/900 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 1.10 Cls=09(hub ) Sub=00 Prot=00 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic uhci_hcd S: Product=UHCI Host Controller S: SerialNumber=0000:00:1d.2 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=255ms T: Bus=03 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=12 MxCh= 2 B: Alloc= 0/900 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 1.10 Cls=09(hub ) Sub=00 Prot=00 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic uhci_hcd S: Product=UHCI Host Controller S: SerialNumber=0000:00:1d.1 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=255ms T: Bus=02 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=12 MxCh= 2 B: Alloc= 0/900 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 1.10 Cls=09(hub ) Sub=00 Prot=00 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic uhci_hcd S: Product=UHCI Host Controller S: SerialNumber=0000:00:1d.0 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=255ms T: Bus=01 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=480 MxCh= 6 B: Alloc= 0/800 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 2.00 Cls=09(hub ) Sub=00 Prot=01 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic ehci_hcd S: Product=EHCI Host Controller S: SerialNumber=0000:00:1d.7 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=256ms $ cat /proc/interrupts CPU0 0: 1439132 XT-PIC timer 1: 4630 XT-PIC i8042 2: 0 XT-PIC cascade 7: 2 XT-PIC parport0 8: 3 XT-PIC rtc 9: 4643 XT-PIC acpi 11: 1058243 XT-PIC ehci_hcd:usb1, uhci_hcd:usb2, uhci_hcd:usb3, uhci_hcd:usb4, ohci1394, Intel 82801DB-ICH4, yenta, yenta, wifi0, Intel 82801DB-ICH4 Modem, radeon@pci:0000:01:00.0 12: 119430 XT-PIC i8042 14: 20854 XT-PIC ide0 NMI: 0 LOC: 0 ERR: 0 MIS: 0 $ lsmod | grep usb usbcore 134912 3 uhci_hcd,ehci_hcd OUTPUT OF 2 USB PORT COMPUTER (w/ problems): $ lsusb Bus 004 Device 001: ID 0000:0000 Bus 003 Device 001: ID 0000:0000 Bus 002 Device 001: ID 0000:0000 Bus 001 Device 001: ID 0000:0000 $ lspci 00:1d.0 USB Controller: Intel Corporation 82801DB/DBL/DBM (ICH4/ICH4-L/ICH4-M) USB UHCI Controller #1 (rev 01) 00:1d.1 USB Controller: Intel Corporation 82801DB/DBL/DBM (ICH4/ICH4-L/ICH4-M) USB UHCI Controller #2 (rev 01) 00:1d.2 USB Controller: Intel Corporation 82801DB/DBL/DBM (ICH4/ICH4-L/ICH4-M) USB UHCI Controller #3 (rev 01) 00:1d.7 USB Controller: Intel Corporation 82801DB/DBM (ICH4/ICH4-M) USB2 EHCI Controller (rev 01) $ cat /proc/bus/usb/devices T: Bus=04 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=480 MxCh= 6 B: Alloc= 0/800 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 2.00 Cls=09(hub ) Sub=00 Prot=01 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic ehci_hcd S: Product=EHCI Host Controller S: SerialNumber=0000:00:1d.7 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=256ms T: Bus=03 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=12 MxCh= 2 B: Alloc= 0/900 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 1.10 Cls=09(hub ) Sub=00 Prot=00 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic uhci_hcd S: Product=UHCI Host Controller S: SerialNumber=0000:00:1d.2 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=255ms T: Bus=02 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=12 MxCh= 2 B: Alloc= 0/900 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 1.10 Cls=09(hub ) Sub=00 Prot=00 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic uhci_hcd S: Product=UHCI Host Controller S: SerialNumber=0000:00:1d.1 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=255ms T: Bus=01 Lev=00 Prnt=00 Port=00 Cnt=00 Dev#= 1 Spd=12 MxCh= 2 B: Alloc= 0/900 us ( 0%), #Int= 0, #Iso= 0 D: Ver= 1.10 Cls=09(hub ) Sub=00 Prot=00 MxPS=64 #Cfgs= 1 P: Vendor=0000 ProdID=0000 Rev= 2.06 S: Manufacturer=Linux 2.6.17-10-generic uhci_hcd S: Product=UHCI Host Controller S: SerialNumber=0000:00:1d.0 C:* #Ifs= 1 Cfg#= 1 Atr=e0 MxPwr= 0mA I: If#= 0 Alt= 0 #EPs= 1 Cls=09(hub ) Sub=00 Prot=00 Driver=hub E: Ad=81(I) Atr=03(Int.) MxPS= 2 Ivl=255ms $ cat /proc/interrupts CPU0 0: 223892 XT-PIC timer 1: 687 XT-PIC i8042 2: 0 XT-PIC cascade 7: 0 XT-PIC parport0 8: 3 XT-PIC rtc 9: 1031 XT-PIC acpi 11: 188219 XT-PIC uhci_hcd:usb1, uhci_hcd:usb2, uhci_hcd:usb3, Intel 82801DB-ICH4, wifi0, yenta, yenta, radeon@pci:0000:01:00.0, ehci_hcd:usb4 12: 45782 XT-PIC i8042 14: 6048 XT-PIC ide0 15: 7825 XT-PIC ide1 NMI: 0 LOC: 0 ERR: 0 MIS: 0 $ lsmod | grep usb usb_storage 75072 0 scsi_mod 144648 3 sg,sd_mod,usb_storage libusual 17040 1 usb_storage usbcore 134912 5 ehci_hcd,usb_storage,libusual,uhci_hcd