I do not believe this is a duplicate; It is more likely a *packaging* issue. The question remains for this bug, why does it only appear in the focal kernels; but not Eoan or older? And if someone could confirm whether or not the linux-generic or linux-modules generate this file and when (unpack, deb postinst, kernel install hook?) Another reason why this isn't a duplicate as the error message is unrelated to the contents of the initrd, but rather when depmod -a -S is called (postins of linux-modules package). On Eoan we can remove the file in question and regenerate the file with: depmod -a -F /boot/System.map-5.3.0-40-generic; this command does not produce the error message on any release expect Focal. # eoan root@rharper-e1:~# cat /etc/issue Ubuntu 19.10 \n \l root@rharper-e1:~# dpkg --list | grep linux- ii linux-base 4.5ubuntu2 all Linux image base package ii linux-firmware 1.183.4 all Firmware for Linux kernel drivers ii linux-generic 5.3.0.40.34 amd64 Complete Generic Linux kernel and headers ii linux-headers-5.3.0-40 5.3.0-40.32 all Header files related to Linux kernel version 5.3.0 ii linux-headers-5.3.0-40-generic 5.3.0-40.32 amd64 Linux kernel headers for version 5.3.0 on 64 bit x86 SMP ii linux-headers-generic 5.3.0.40.34 amd64 Generic Linux kernel headers ii linux-image-5.3.0-40-generic 5.3.0-40.32 amd64 Signed kernel image generic ii linux-image-generic 5.3.0.40.34 amd64 Generic Linux kernel image ii linux-modules-5.3.0-40-generic 5.3.0-40.32 amd64 Linux kernel extra modules for version 5.3.0 on 64 bit x86 SMP ii linux-modules-extra-5.3.0-40-generic 5.3.0-40.32 amd64 Linux kernel extra modules for version 5.3.0 on 64 bit x86 SMP root@rharper-e1:~# rm /lib/modules/5.3.0-40-generic/modules.builtin.bin root@rharper-e1:~# depmod -a -F /boot/System.map-5.3.0-40-generic 5.3.0-40-generic root@rharper-e1:~# ls -al /lib/modules/5.3.0-40-generic/modules.builtin.bin -rw-r--r-- 1 root root 9943 Mar 2 15:03 /lib/modules/5.3.0-40-generic/modules.builtin.bin # On focal this errors: root@rharper-f1:~# cat /etc/issue Ubuntu Focal Fossa (development branch) \n \l root@rharper-f1:~# dpkg --list | grep linux- ii linux-5.4-headers-5.4.0-14 5.4.0-14.17 all Header files related to Linux kernel version 5.4.0 ii linux-base 4.5ubuntu2 all Linux image base package ii linux-firmware 1.186 all Firmware for Linux kernel drivers ii linux-generic 5.4.0.14.17 amd64 Complete Generic Linux kernel and headers ii linux-headers-5.4.0-14-generic 5.4.0-14.17 amd64 Linux kernel headers for version 5.4.0 on 64 bit x86 SMP ii linux-headers-generic 5.4.0.14.17 amd64 Generic Linux kernel headers ii linux-image-5.4.0-14-generic 5.4.0-14.17 amd64 Signed kernel image generic ii linux-image-generic 5.4.0.14.17 amd64 Generic Linux kernel image ii linux-modules-5.4.0-14-generic 5.4.0-14.17 amd64 Linux kernel extra modules for version 5.4.0 on 64 bit x86 SMP ii linux-modules-extra-5.4.0-14-generic 5.4.0-14.17 amd64 Linux kernel extra modules for version 5.4.0 on 64 bit x86 SMP root@rharper-f1:~# ls -al /lib/modules/5.4.0-14-generic/modules.builtin.bin -rw-r--r-- 1 root root 10257 Mar 2 15:01 /lib/modules/5.4.0-14-generic/modules.builtin.bin root@rharper-f1:~# set -o vi root@rharper-f1:~# rm /lib/modules/5.4.0-14-generic/modules.builtin.bin root@rharper-f1:~# depmod -a -F /boot/System.map-5.4.0-14-generic 5.4.0-14-generic depmod: ERROR: ../libkmod/libkmod.c:515 lookup_builtin_file() could not open builtin file '/lib/modules/5.4.0-14-generic/modules.builtin.bin' depmod: ERROR: ../libkmod/libkmod.c:515 lookup_builtin_file() could not open builtin file '/lib/modules/5.4.0-14-generic/modules.builtin.bin' depmod: ERROR: ../libkmod/libkmod.c:515 lookup_builtin_file() could not open builtin file '/lib/modules/5.4.0-14-generic/modules.builtin.bin' depmod: ERROR: ../libkmod/libkmod.c:515 lookup_builtin_file() could not open builtin file '/lib/modules/5.4.0-14-generic/modules.builtin.bin'