There is a regression on 16.04. I don't think it's a duplicate of https://bugs.launchpad.net/ubuntu/+source/lsb/+bug/840998: that was caused by a broken symlink to  /lib/x86_64-linux-gnu/ld-2.23.so; this is not the case.

ignazio@ignazio-HP-ZBook-17:/opt/epson-inkjet-printer-escpr/cups/lib/filter$ ./epson-escpr-wrapper 
bash: ./epson-escpr-wrapper: No such file or directory

ignazio@ignazio-HP-ZBook-17:/opt/epson-inkjet-printer-escpr/cups/lib/filter$ ldd epson-escpr-wrapper 
	linux-vdso.so.1 =>  (0x00007ffdc3f7a000)
	libcupsimage.so.2 => /usr/lib/x86_64-linux-gnu/libcupsimage.so.2 (0x00007f0ce852c000)
	libcups.so.2 => /usr/lib/x86_64-linux-gnu/libcups.so.2 (0x00007f0ce82ac000)
	libpthread.so.0 => /lib/x86_64-linux-gnu/libpthread.so.0 (0x00007f0ce808e000)
	libm.so.6 => /lib/x86_64-linux-gnu/libm.so.6 (0x00007f0ce7d85000)
	libc.so.6 => /lib/x86_64-linux-gnu/libc.so.6 (0x00007f0ce79bb000)
	libgssapi_krb5.so.2 => /usr/lib/x86_64-linux-gnu/libgssapi_krb5.so.2 (0x00007f0ce7770000)
	libgnutls.so.30 => /usr/lib/x86_64-linux-gnu/libgnutls.so.30 (0x00007f0ce743f000)
	libavahi-common.so.3 => /usr/lib/x86_64-linux-gnu/libavahi-common.so.3 (0x00007f0ce7233000)
	libavahi-client.so.3 => /usr/lib/x86_64-linux-gnu/libavahi-client.so.3 (0x00007f0ce7021000)
	libz.so.1 => /lib/x86_64-linux-gnu/libz.so.1 (0x00007f0ce6e07000)
	/lib64/ld-lsb-x86-64.so.3 => /lib64/ld-linux-x86-64.so.2 (0x000055ed62393000)
	libkrb5.so.3 => /usr/lib/x86_64-linux-gnu/libkrb5.so.3 (0x00007f0ce6b35000)
	libk5crypto.so.3 => /usr/lib/x86_64-linux-gnu/libk5crypto.so.3 (0x00007f0ce6905000)
	libcom_err.so.2 => /lib/x86_64-linux-gnu/libcom_err.so.2 (0x00007f0ce6701000)
	libkrb5support.so.0 => /usr/lib/x86_64-linux-gnu/libkrb5support.so.0 (0x00007f0ce64f6000)
	libp11-kit.so.0 => /usr/lib/x86_64-linux-gnu/libp11-kit.so.0 (0x00007f0ce6290000)
	libidn.so.11 => /usr/lib/x86_64-linux-gnu/libidn.so.11 (0x00007f0ce605d000)
	libtasn1.so.6 => /usr/lib/x86_64-linux-gnu/libtasn1.so.6 (0x00007f0ce5e4a000)
	libnettle.so.6 => /usr/lib/x86_64-linux-gnu/libnettle.so.6 (0x00007f0ce5c13000)
	libhogweed.so.4 => /usr/lib/x86_64-linux-gnu/libhogweed.so.4 (0x00007f0ce59e0000)
	libgmp.so.10 => /usr/lib/x86_64-linux-gnu/libgmp.so.10 (0x00007f0ce5760000)
	libdbus-1.so.3 => /lib/x86_64-linux-gnu/libdbus-1.so.3 (0x00007f0ce5513000)
	libdl.so.2 => /lib/x86_64-linux-gnu/libdl.so.2 (0x00007f0ce530f000)
	libkeyutils.so.1 => /lib/x86_64-linux-gnu/libkeyutils.so.1 (0x00007f0ce510b000)
	libresolv.so.2 => /lib/x86_64-linux-gnu/libresolv.so.2 (0x00007f0ce4eef000)
	libffi.so.6 => /usr/lib/x86_64-linux-gnu/libffi.so.6 (0x00007f0ce4ce7000)
	libsystemd.so.0 => /lib/x86_64-linux-gnu/libsystemd.so.0 (0x00007f0ce4c61000)
	libselinux.so.1 => /lib/x86_64-linux-gnu/libselinux.so.1 (0x00007f0ce4a3f000)
	librt.so.1 => /lib/x86_64-linux-gnu/librt.so.1 (0x00007f0ce4837000)
	liblzma.so.5 => /lib/x86_64-linux-gnu/liblzma.so.5 (0x00007f0ce4614000)
	libgcrypt.so.20 => /lib/x86_64-linux-gnu/libgcrypt.so.20 (0x00007f0ce4333000)
	libpcre.so.3 => /lib/x86_64-linux-gnu/libpcre.so.3 (0x00007f0ce40c3000)
	libgpg-error.so.0 => /lib/x86_64-linux-gnu/libgpg-error.so.0 (0x00007f0ce3eae000)

ignazio@ignazio-HP-ZBook-17:/opt/epson-inkjet-printer-escpr/cups/lib/filter$ file epson-escpr-wrapper 
epson-escpr-wrapper: ELF 64-bit LSB executable, x86-64, version 1 (SYSV), dynamically linked, interpreter /lib64/ld-lsb-x86-64.so.3, for GNU/Linux 2.6.15, BuildID[sha1]=558bd286d0e69cd3994a848c7c04d09a026cc2c4, stripped

ignazio@ignazio-HP-ZBook-17:/opt/epson-inkjet-printer-escpr/cups/lib/filter$ file /lib64/ld-linux-x86-64.so.2 
/lib64/ld-linux-x86-64.so.2: symbolic link to /lib/x86_64-linux-gnu/ld-2.23.so