Here is another similar situation. Note that the second execution of the prepared statement returns no rows, whereas the first execution of the prepared statement and the stand-alone execution of the statement return rows:

SET SESSION optimizer_switch = 'semijoin=off';

--disable_warnings
DROP TABLE /*! IF EXISTS */ D;
DROP TABLE /*! IF EXISTS */ C;
DROP TABLE /*! IF EXISTS */ BB;
DROP TABLE /*! IF EXISTS */ B;
--enable_warnings

CREATE TABLE `D` (
  `pk` int(11) NOT NULL AUTO_INCREMENT,
  `col_int_key` int(11) DEFAULT NULL,
  `col_time_key` time DEFAULT NULL,
  `col_varchar_key` varchar(1) DEFAULT NULL,
  `col_varchar_nokey` varchar(1) DEFAULT NULL,
  PRIMARY KEY (`pk`),
  KEY `col_int_key` (`col_int_key`),
  KEY `col_time_key` (`col_time_key`),
  KEY `col_varchar_key` (`col_varchar_key`,`col_int_key`)
) ENGINE=MyISAM AUTO_INCREMENT=101 DEFAULT CHARSET=latin1;
INSERT INTO `D` VALUES (1,NULL,NULL,'r','r');
INSERT INTO `D` VALUES (2,0,'14:34:45','c','c');
INSERT INTO `D` VALUES (3,0,'11:49:48','o','o');
INSERT INTO `D` VALUES (4,7,'18:12:55','c','c');
INSERT INTO `D` VALUES (5,8,'18:30:05','d','d');
INSERT INTO `D` VALUES (6,4,'14:19:30','v','v');
INSERT INTO `D` VALUES (7,6,'05:20:04','m','m');
INSERT INTO `D` VALUES (8,5,'20:29:31','j','j');
INSERT INTO `D` VALUES (9,NULL,'07:08:09','f','f');
INSERT INTO `D` VALUES (10,NULL,'14:49:14','n','n');
INSERT INTO `D` VALUES (11,8,'00:00:00','z','z');
INSERT INTO `D` VALUES (12,8,'09:58:06','h','h');
INSERT INTO `D` VALUES (13,8,NULL,'q','q');
INSERT INTO `D` VALUES (14,1,'18:24:16','w','w');
INSERT INTO `D` VALUES (15,1,'17:39:57','z','z');
INSERT INTO `D` VALUES (16,5,'08:23:21','j','j');
INSERT INTO `D` VALUES (17,2,NULL,'a','a');
INSERT INTO `D` VALUES (18,7,'21:50:46','m','m');
INSERT INTO `D` VALUES (19,6,'12:33:17','n','n');
INSERT INTO `D` VALUES (20,4,'03:06:43','e','e');
INSERT INTO `D` VALUES (21,7,'03:46:14','u','u');
INSERT INTO `D` VALUES (22,0,'20:34:52','s','s');
INSERT INTO `D` VALUES (23,9,NULL,'u','u');
INSERT INTO `D` VALUES (24,3,'10:41:20','r','r');
INSERT INTO `D` VALUES (25,5,'08:43:11','g','g');
INSERT INTO `D` VALUES (26,1,NULL,'o','o');
INSERT INTO `D` VALUES (27,1,'10:17:51','w','w');
INSERT INTO `D` VALUES (28,5,'06:34:09','b','b');
INSERT INTO `D` VALUES (29,9,'21:22:47',NULL,NULL);
INSERT INTO `D` VALUES (30,2,'04:02:32','y','y');
INSERT INTO `D` VALUES (31,5,'02:33:14','y','y');
INSERT INTO `D` VALUES (32,248,'16:32:56','u','u');
INSERT INTO `D` VALUES (33,0,'21:32:42','p','p');
INSERT INTO `D` VALUES (34,8,'23:04:47','s','s');
INSERT INTO `D` VALUES (35,1,'22:05:43','e','e');
INSERT INTO `D` VALUES (36,255,'02:05:45','d','d');
INSERT INTO `D` VALUES (37,9,'00:00:00','d','d');
INSERT INTO `D` VALUES (38,9,'18:09:07','c','c');
INSERT INTO `D` VALUES (39,3,'10:54:06','b','b');
INSERT INTO `D` VALUES (40,9,'23:15:50','t','t');
INSERT INTO `D` VALUES (41,6,'10:17:40',NULL,NULL);
INSERT INTO `D` VALUES (42,4,'03:37:09','y','y');
INSERT INTO `D` VALUES (43,60,'22:26:06','c','c');
INSERT INTO `D` VALUES (44,7,'17:10:38','d','d');
INSERT INTO `D` VALUES (45,1,'00:00:00','x','x');
INSERT INTO `D` VALUES (46,6,'17:08:49','p','p');
INSERT INTO `D` VALUES (47,4,'19:04:40','e','e');
INSERT INTO `D` VALUES (48,NULL,'20:53:28','g','g');
INSERT INTO `D` VALUES (49,8,'11:46:03','x','x');
INSERT INTO `D` VALUES (50,0,NULL,'s','s');
INSERT INTO `D` VALUES (51,8,'10:58:07','e','e');
INSERT INTO `D` VALUES (52,151,'00:00:00','l','l');
INSERT INTO `D` VALUES (53,7,'09:43:15','p','p');
INSERT INTO `D` VALUES (54,6,'21:40:32','h','h');
INSERT INTO `D` VALUES (55,NULL,'00:17:44','m','m');
INSERT INTO `D` VALUES (56,23,'16:47:26','n','n');
INSERT INTO `D` VALUES (57,2,'00:00:00','v','v');
INSERT INTO `D` VALUES (58,4,'05:25:59','b','b');
INSERT INTO `D` VALUES (59,NULL,'00:00:00','x','x');
INSERT INTO `D` VALUES (60,NULL,'20:33:04','r','r');
INSERT INTO `D` VALUES (61,77,'00:46:12','t','t');
INSERT INTO `D` VALUES (62,NULL,'00:00:00','w','w');
INSERT INTO `D` VALUES (63,NULL,'02:13:59','w','w');
INSERT INTO `D` VALUES (64,7,'02:54:47','k','k');
INSERT INTO `D` VALUES (65,1,'18:13:59','a','a');
INSERT INTO `D` VALUES (66,9,'13:53:08','t','t');
INSERT INTO `D` VALUES (67,6,'22:21:30','z','z');
INSERT INTO `D` VALUES (68,2,'11:41:50','e','e');
INSERT INTO `D` VALUES (69,3,'15:20:02','q','q');
INSERT INTO `D` VALUES (70,0,NULL,'e','e');
INSERT INTO `D` VALUES (71,NULL,NULL,'v','v');
INSERT INTO `D` VALUES (72,6,'07:51:52','d','d');
INSERT INTO `D` VALUES (73,3,'00:00:00','u','u');
INSERT INTO `D` VALUES (74,195,NULL,'o','o');
INSERT INTO `D` VALUES (75,5,NULL,'b','b');
INSERT INTO `D` VALUES (76,2,'12:31:05','c','c');
INSERT INTO `D` VALUES (77,7,'00:00:00','q','q');
INSERT INTO `D` VALUES (78,25,'01:16:45',NULL,NULL);
INSERT INTO `D` VALUES (79,NULL,'20:38:54','h','h');
INSERT INTO `D` VALUES (80,0,'00:30:15','d','d');
INSERT INTO `D` VALUES (81,98,'23:46:36','w','w');
INSERT INTO `D` VALUES (82,6,'19:03:13','m','m');
INSERT INTO `D` VALUES (83,5,'10:54:27','i','i');
INSERT INTO `D` VALUES (84,0,'00:25:47','w','w');
INSERT INTO `D` VALUES (85,3,'08:44:27','f','f');
INSERT INTO `D` VALUES (86,1,'08:15:38','k','k');
INSERT INTO `D` VALUES (87,1,'19:56:21','v','v');
INSERT INTO `D` VALUES (88,147,'00:00:00','c','c');
INSERT INTO `D` VALUES (89,3,'20:50:52','y','y');
INSERT INTO `D` VALUES (90,3,'03:54:39','h','h');
INSERT INTO `D` VALUES (91,NULL,'23:58:17',NULL,NULL);
INSERT INTO `D` VALUES (92,2,'12:54:58','t','t');
INSERT INTO `D` VALUES (93,1,'04:02:43','l','l');
INSERT INTO `D` VALUES (94,8,'11:31:12','a','a');
INSERT INTO `D` VALUES (95,8,'20:20:04','r','r');
INSERT INTO `D` VALUES (96,8,'00:22:24','s','s');
INSERT INTO `D` VALUES (97,0,'10:09:31','z','z');
INSERT INTO `D` VALUES (98,1,NULL,'j','j');
INSERT INTO `D` VALUES (99,8,'18:45:35','c','c');
INSERT INTO `D` VALUES (100,5,'11:49:25','f','f');
CREATE TABLE `C` (
  `pk` int(11) NOT NULL AUTO_INCREMENT,
  `col_int_key` int(11) DEFAULT NULL,
  `col_time_key` time DEFAULT NULL,
  `col_varchar_key` varchar(1) DEFAULT NULL,
  `col_varchar_nokey` varchar(1) DEFAULT NULL,
  PRIMARY KEY (`pk`),
  KEY `col_int_key` (`col_int_key`),
  KEY `col_time_key` (`col_time_key`),
  KEY `col_varchar_key` (`col_varchar_key`,`col_int_key`)
) ENGINE=MyISAM AUTO_INCREMENT=21 DEFAULT CHARSET=latin1;
INSERT INTO `C` VALUES (1,2,'11:28:45','w','w');
INSERT INTO `C` VALUES (2,9,'20:25:14','m','m');
INSERT INTO `C` VALUES (3,3,'13:47:24','m','m');
INSERT INTO `C` VALUES (4,9,'19:24:11','k','k');
INSERT INTO `C` VALUES (5,NULL,'15:59:13','r','r');
INSERT INTO `C` VALUES (6,9,'00:00:00','t','t');
INSERT INTO `C` VALUES (7,3,'15:15:04','j','j');
INSERT INTO `C` VALUES (8,8,'11:32:06','u','u');
INSERT INTO `C` VALUES (9,8,'18:32:33','h','h');
INSERT INTO `C` VALUES (10,53,'15:19:25','o','o');
INSERT INTO `C` VALUES (11,0,'19:03:19',NULL,NULL);
INSERT INTO `C` VALUES (12,5,'00:39:46','k','k');
INSERT INTO `C` VALUES (13,166,NULL,'e','e');
INSERT INTO `C` VALUES (14,3,'00:00:00','n','n');
INSERT INTO `C` VALUES (15,0,'13:12:11','t','t');
INSERT INTO `C` VALUES (16,1,'04:56:48','c','c');
INSERT INTO `C` VALUES (17,9,'19:56:05','m','m');
INSERT INTO `C` VALUES (18,5,'19:35:19','y','y');
INSERT INTO `C` VALUES (19,6,'05:03:03','f','f');
INSERT INTO `C` VALUES (20,2,'18:38:59','d','d');
CREATE TABLE `BB` (
  `pk` int(11) NOT NULL AUTO_INCREMENT,
  `col_int_key` int(11) DEFAULT NULL,
  `col_time_key` time DEFAULT NULL,
  `col_varchar_key` varchar(1) DEFAULT NULL,
  `col_varchar_nokey` varchar(1) DEFAULT NULL,
  PRIMARY KEY (`pk`),
  KEY `col_int_key` (`col_int_key`),
  KEY `col_time_key` (`col_time_key`),
  KEY `col_varchar_key` (`col_varchar_key`,`col_int_key`)
) ENGINE=MyISAM AUTO_INCREMENT=11 DEFAULT CHARSET=latin1;
INSERT INTO `BB` VALUES (10,8,'18:27:58',NULL,NULL);
CREATE TABLE `B` (
  `pk` int(11) NOT NULL AUTO_INCREMENT,
  `col_int_key` int(11) DEFAULT NULL,
  `col_time_key` time DEFAULT NULL,
  `col_varchar_key` varchar(1) DEFAULT NULL,
  `col_varchar_nokey` varchar(1) DEFAULT NULL,
  PRIMARY KEY (`pk`),
  KEY `col_int_key` (`col_int_key`),
  KEY `col_time_key` (`col_time_key`),
  KEY `col_varchar_key` (`col_varchar_key`,`col_int_key`)
) ENGINE=MyISAM AUTO_INCREMENT=2 DEFAULT CHARSET=latin1;
INSERT INTO `B` VALUES (1,7,'01:13:38','f','f');

SELECT table1 .`col_time_key`  FROM (  SELECT SUBQUERY1_t1 .* FROM BB SUBQUERY1_t1  JOIN C SUBQUERY1_t2  ON SUBQUERY1_t2 .`col_int_key`  = SUBQUERY1_t1 .`pk`  ) table1  RIGHT  JOIN (  SELECT * FROM B  ) table2  JOIN D table3  ON table3 .`col_varchar_key`  = table2 .`col_varchar_key`  ON table3 .`col_varchar_key`  = table2 .`col_varchar_nokey`  WHERE ( table2 .`col_varchar_key`  , table1 .`col_varchar_key`  )  IN (  SELECT SUBQUERY3_t1 .`col_varchar_key`  , SUBQUERY3_t2 .`col_varchar_nokey`  FROM C SUBQUERY3_t1  STRAIGHT_JOIN B SUBQUERY3_t2  ON SUBQUERY3_t1 .`col_varchar_key`  );

PREPARE prep_stmt_7707 FROM " SELECT table1 .`col_time_key`  FROM (  SELECT SUBQUERY1_t1 .* FROM BB SUBQUERY1_t1  JOIN C SUBQUERY1_t2  ON SUBQUERY1_t2 .`col_int_key`  = SUBQUERY1_t1 .`pk`  ) table1  RIGHT  JOIN (  SELECT * FROM B  ) table2  JOIN D table3  ON table3 .`col_varchar_key`  = table2 .`col_varchar_key`  ON table3 .`col_varchar_key`  = table2 .`col_varchar_nokey`  WHERE ( table2 .`col_varchar_key`  , table1 .`col_varchar_key`  )  IN (  SELECT SUBQUERY3_t1 .`col_varchar_key`  , SUBQUERY3_t2 .`col_varchar_nokey`  FROM C SUBQUERY3_t1  STRAIGHT_JOIN B SUBQUERY3_t2  ON SUBQUERY3_t1 .`col_varchar_key`  )   ";
EXECUTE prep_stmt_7707 ;
EXECUTE prep_stmt_7707 ;
DEALLOCATE PREPARE prep_stmt_7707;