I have 2 running virtual machines.  

1.  Ubuntu Server 16.04 acting as a headless game server
2.  Windows 10 Pro used for gaming and other daily activities

I too can start/stop the Win 10 vm for a period of time after a cold boot but if it is logged in for a certain period of time, when I go to shut it down the entire system will freeze.    I can reboot the Ubuntu server at will.  It too has a SSD being passed thru.
 
Win 10 VM
<domain type='kvm' id='3'>
  <name>csmccarronwx00</name>
  <uuid>82c5e4f6-6991-cd5f-8207-49db04386cc9</uuid>
  <description>csmccarronwx00 i440fx-2.5 OVMF</description>
  <metadata>
    <vmtemplate xmlns="unraid" name="Windows 10" icon="windows.png" os="windows10"/>
  </metadata>
  <memory unit='KiB'>11010048</memory>
  <currentMemory unit='KiB'>11010048</currentMemory>
  <memoryBacking>
    <nosharepages/>
    <locked/>
  </memoryBacking>
  <vcpu placement='static'>12</vcpu>
  <cputune>
    <vcpupin vcpu='0' cpuset='6'/>
    <vcpupin vcpu='1' cpuset='18'/>
    <vcpupin vcpu='2' cpuset='7'/>
    <vcpupin vcpu='3' cpuset='19'/>
    <vcpupin vcpu='4' cpuset='8'/>
    <vcpupin vcpu='5' cpuset='20'/>
    <vcpupin vcpu='6' cpuset='9'/>
    <vcpupin vcpu='7' cpuset='21'/>
    <vcpupin vcpu='8' cpuset='10'/>
    <vcpupin vcpu='9' cpuset='22'/>
    <vcpupin vcpu='10' cpuset='11'/>
    <vcpupin vcpu='11' cpuset='23'/>
    <emulatorpin cpuset='1-3,13-15'/>
  </cputune>
  <resource>
    <partition>/machine</partition>
  </resource>
  <os>
    <type arch='x86_64' machine='pc-i440fx-2.5'>hvm</type>
    <loader readonly='yes' type='pflash'>/usr/share/qemu/ovmf-x64/OVMF_CODE-pure-efi.fd</loader>
    <nvram>/etc/libvirt/qemu/nvram/82c5e4f6-6991-cd5f-8207-49db04386cc9_VARS-pure-efi.fd</nvram>
    <boot dev='cdrom'/>
    <boot dev='hd'/>
    <bootmenu enable='yes' timeout='3000'/>
  </os>
  <features>
    <acpi/>
    <apic/>
  </features>
  <cpu mode='host-passthrough'>
    <topology sockets='1' cores='6' threads='2'/>
  </cpu>
  <clock offset='localtime'>
    <timer name='rtc' tickpolicy='catchup'/>
    <timer name='pit' tickpolicy='delay'/>
    <timer name='hpet' present='no'/>
  </clock>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>restart</on_crash>
  <devices>
    <emulator>/usr/local/sbin/qemu</emulator>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/mnt/user/ISO/virtio-win-0.1.117.iso'/>
      <backingStore/>
      <target dev='hda' bus='sata'/>
      <readonly/>
      <alias name='sata0-0-0'/>
      <address type='drive' controller='0' bus='0' target='0' unit='0'/>
    </disk>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/mnt/user/ISO/Windows10Pro_TH2.iso'/>
      <backingStore/>
      <target dev='hdb' bus='sata'/>
      <readonly/>
      <alias name='sata0-0-1'/>
      <address type='drive' controller='0' bus='0' target='0' unit='1'/>
    </disk>
    <disk type='block' device='disk'>
      <driver name='qemu' type='raw' cache='writeback'/>
      <source dev='/dev/disk/by-id/ata-Samsung_SSD_850_PRO_256GB_S1SUNSAG361503D'/>
      <backingStore/>
      <target dev='hdc' bus='virtio'/>
      <alias name='virtio-disk2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0a' function='0x0'/>
    </disk>
    <disk type='block' device='disk'>
      <driver name='qemu' type='raw' cache='writeback'/>
      <source dev='/dev/disk/by-id/ata-SanDisk_Ultra_II_480GB_161322801967'/>
      <backingStore/>
      <target dev='hdd' bus='virtio'/>
      <alias name='virtio-disk3'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0b' function='0x0'/>
    </disk>
    <controller type='usb' index='0' model='ich9-ehci1'>
      <alias name='usb'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x7'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci1'>
      <alias name='usb'/>
      <master startport='0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x0' multifunction='on'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci2'>
      <alias name='usb'/>
      <master startport='2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x1'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci3'>
      <alias name='usb'/>
      <master startport='4'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x2'/>
    </controller>
    <controller type='pci' index='0' model='pci-root'>
      <alias name='pci.0'/>
    </controller>
    <controller type='sata' index='0'>
      <alias name='sata0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x03' function='0x0'/>
    </controller>
    <controller type='virtio-serial' index='0'>
      <alias name='virtio-serial0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x04' function='0x0'/>
    </controller>
    <interface type='bridge'>
      <mac address='52:54:00:86:5a:91'/>
      <source bridge='br0'/>
      <target dev='vnet0'/>
      <model type='virtio'/>
      <alias name='net0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0'/>
    </interface>
    <serial type='pty'>
      <source path='/dev/pts/2'/>
      <target port='0'/>
      <alias name='serial0'/>
    </serial>
    <console type='pty' tty='/dev/pts/2'>
      <source path='/dev/pts/2'/>
      <target type='serial' port='0'/>
      <alias name='serial0'/>
    </console>
    <channel type='unix'>
      <source mode='bind' path='/var/lib/libvirt/qemu/channel/target/domain-csmccarronwx00/org.qemu.guest_agent.0'/>
      <target type='virtio' name='org.qemu.guest_agent.0' state='disconnected'/>
      <alias name='channel0'/>
      <address type='virtio-serial' controller='0' bus='0' port='1'/>
    </channel>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <driver name='vfio'/>
      <source>
        <address domain='0x0000' bus='0x0a' slot='0x00' function='0x0'/>
      </source>
      <alias name='hostdev0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <driver name='vfio'/>
      <source>
        <address domain='0x0000' bus='0x0a' slot='0x00' function='0x1'/>
      </source>
      <alias name='hostdev1'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <driver name='vfio'/>
      <source>
        <address domain='0x0000' bus='0x0c' slot='0x00' function='0x0'/>
      </source>
      <alias name='hostdev2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x08' function='0x0'/>
    </hostdev>
    <memballoon model='virtio'>
      <alias name='balloon0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x09' function='0x0'/>
    </memballoon>
  </devices>
</domain>

Ubuntu Server VM
<domain type='kvm' id='2'>
  <name>Ubuntu Server</name>
  <uuid>232de5eb-2276-0762-2e29-29dc917ef34d</uuid>
  <description>Ubuntu Server Q35 OVMF</description>
  <metadata>
    <vmtemplate xmlns="unraid" name="Ubuntu" icon="ubuntu.png" os="ubuntu"/>
  </metadata>
  <memory unit='KiB'>11010048</memory>
  <currentMemory unit='KiB'>11010048</currentMemory>
  <memoryBacking>
    <nosharepages/>
  </memoryBacking>
  <vcpu placement='static'>4</vcpu>
  <cputune>
    <vcpupin vcpu='0' cpuset='4'/>
    <vcpupin vcpu='1' cpuset='16'/>
    <vcpupin vcpu='2' cpuset='5'/>
    <vcpupin vcpu='3' cpuset='17'/>
    <emulatorpin cpuset='1-3,13-15'/>
  </cputune>
  <resource>
    <partition>/machine</partition>
  </resource>
  <os>
    <type arch='x86_64' machine='pc-q35-2.5'>hvm</type>
    <loader readonly='yes' type='pflash'>/usr/share/qemu/ovmf-x64/OVMF_CODE-pure-efi.fd</loader>
    <nvram>/etc/libvirt/qemu/nvram/232de5eb-2276-0762-2e29-29dc917ef34d_VARS-pure-efi.fd</nvram>
  </os>
  <features>
    <acpi/>
    <apic/>
  </features>
  <cpu mode='host-passthrough'>
    <topology sockets='1' cores='2' threads='2'/>
  </cpu>
  <clock offset='utc'>
    <timer name='rtc' tickpolicy='catchup'/>
    <timer name='pit' tickpolicy='delay'/>
    <timer name='hpet' present='no'/>
  </clock>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>restart</on_crash>
  <devices>
    <emulator>/usr/local/sbin/qemu</emulator>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/mnt/user/ISO/gparted-live-0.25.0-3-i686.iso'/>
      <backingStore/>
      <target dev='hda' bus='sata'/>
      <readonly/>
      <boot order='2'/>
      <alias name='sata0-0-0'/>
      <address type='drive' controller='0' bus='0' target='0' unit='0'/>
    </disk>
    <disk type='block' device='disk'>
      <driver name='qemu' type='raw' cache='writeback'/>
      <source dev='/dev/disk/by-id/ata-SanDisk_Ultra_II_480GB_161002808956'/>
      <backingStore/>
      <target dev='hdd' bus='virtio'/>
      <boot order='1'/>
      <alias name='virtio-disk3'/>
      <address type='pci' domain='0x0000' bus='0x02' slot='0x04' function='0x0'/>
    </disk>
    <controller type='usb' index='0' model='ich9-ehci1'>
      <alias name='usb'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x7'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci1'>
      <alias name='usb'/>
      <master startport='0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x0' multifunction='on'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci2'>
      <alias name='usb'/>
      <master startport='2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x1'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci3'>
      <alias name='usb'/>
      <master startport='4'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x2'/>
    </controller>
    <controller type='sata' index='0'>
      <alias name='ide'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1f' function='0x2'/>
    </controller>
    <controller type='pci' index='0' model='pcie-root'>
      <alias name='pcie.0'/>
    </controller>
    <controller type='pci' index='1' model='dmi-to-pci-bridge'>
      <model name='i82801b11-bridge'/>
      <alias name='pci.1'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x1e' function='0x0'/>
    </controller>
    <controller type='pci' index='2' model='pci-bridge'>
      <model name='pci-bridge'/>
      <target chassisNr='2'/>
      <alias name='pci.2'/>
      <address type='pci' domain='0x0000' bus='0x01' slot='0x01' function='0x0'/>
    </controller>
    <controller type='virtio-serial' index='0'>
      <alias name='virtio-serial0'/>
      <address type='pci' domain='0x0000' bus='0x02' slot='0x03' function='0x0'/>
    </controller>
    <filesystem type='mount' accessmode='passthrough'>
      <source dir='/mnt/user/Apps/'/>
      <target dir='Apps'/>
      <alias name='fs0'/>
      <address type='pci' domain='0x0000' bus='0x02' slot='0x01' function='0x0'/>
    </filesystem>
    <interface type='bridge'>
      <mac address='52:54:00:2b:b9:e2'/>
      <source bridge='br0'/>
      <target dev='vnet1'/>
      <model type='virtio'/>
      <alias name='net0'/>
      <address type='pci' domain='0x0000' bus='0x02' slot='0x02' function='0x0'/>
    </interface>
    <serial type='pty'>
      <source path='/dev/pts/1'/>
      <target port='0'/>
      <alias name='serial0'/>
    </serial>
    <console type='pty' tty='/dev/pts/1'>
      <source path='/dev/pts/1'/>
      <target type='serial' port='0'/>
      <alias name='serial0'/>
    </console>
    <channel type='unix'>
      <source mode='bind' path='/var/lib/libvirt/qemu/channel/target/domain-Ubuntu Server/org.qemu.guest_agent.0'/>
      <target type='virtio' name='org.qemu.guest_agent.0' state='disconnected'/>
      <alias name='channel0'/>
      <address type='virtio-serial' controller='0' bus='0' port='1'/>
    </channel>
    <input type='tablet' bus='usb'>
      <alias name='input0'/>
    </input>
    <input type='mouse' bus='ps2'/>
    <input type='keyboard' bus='ps2'/>
    <graphics type='vnc' port='5900' autoport='yes' websocket='5700' listen='0.0.0.0' keymap='en-us'>
      <listen type='address' address='0.0.0.0'/>
    </graphics>
    <video>
      <model type='qxl' ram='65536' vram='65536' vgamem='16384' heads='1'/>
      <alias name='video0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x0'/>
    </video>
    <memballoon model='virtio'>
      <alias name='balloon0'/>
      <address type='pci' domain='0x0000' bus='0x02' slot='0x05' function='0x0'/>
    </memballoon>
  </devices>
</domain>