Comment 7 for bug 487144

Reproduced with Inkscape 0.48+devel r10101 on OS X 10.5.8. (i386), gtk2 @2.22.1_1+no_x11+quartz:

Also: Inkscape (default, new preferences.xml) fails to open with an empty document if a custom default template explicitly sets a window size (unless 'window->reshow_with_initial_size ();' is commented out as described in comment #5).

Changing the settings for saving & restoring the windows geometry (size &position) in 'Inkscape Preferences > Windows' to
 [x] Don't save window geometry
seems to help as temporary workaround.