I have the exact same problem as Ross Berteig on Vista 32 bit. My Inkscape was working fine for months until today. I uninstalled my avast antivirus yesterday and this is likely the cause. It seems the code is being built for fixed dll load offsets. I tried reinstalling with the latest stable version and installed the bleeding edge version. I believe this could be something like a compilation mode error, because it appears that the liblcms-1.dll is not using dynamic linking properly. Typically when compiled in release mode I thought dlls were allowed to be loaded at any address, but the code in liblcms-1.dll is specifically expecting a dll to be loaded at a specified address (but the dll is not loaded at that address!). Here is some debugging information for the inkscape_r10115-201103191533 Exception occurs at: 0x25118E (liblcms-s.dll + 0x118E): CALL 0x8FC90000 <- Address 0x8FC90000 is unallocated and causes and access violation. Here is the assembly in the area around this instruction: 00251170 55 PUSH EBP 00251171 B8 0000C98F MOV EAX,8FC90000 00251176 89E5 MOV EBP,ESP 00251178 83EC 08 SUB ESP,8 0025117B 85C0 TEST EAX,EAX 0025117D 74 14 JE SHORT liblcms-.00251193 0025117F C74424 04 20F027>MOV DWORD PTR SS:[ESP+4],liblcms-.0027F0> 00251187 C70424 00E52700 MOV DWORD PTR SS:[ESP],liblcms-.0027E500 0025118E E8 6DEEA38F CALL 8FC90000 00251193 A1 90AB2700 MOV EAX,DWORD PTR DS:[27AB90] 00251198 85C0 TEST EAX,EAX 0025119A 74 3A JE SHORT liblcms-.002511D6 0025119C C70424 00B02700 MOV DWORD PTR SS:[ESP],liblcms-.0027B000 ; ASCII "libgcj_s.dll" 002511A3 E8 F88A0200 CALL 002511A8 BA 0000C98F MOV EDX,8FC90000 002511AD 83EC 04 SUB ESP,4 002511B0 85C0 TEST EAX,EAX 002511B2 74 15 JE SHORT liblcms-.002511C9 002511B4 C74424 04 0DB027>MOV DWORD PTR SS:[ESP+4],liblcms-.0027B0>; ASCII "_Jv_RegisterClasses" 002511BC 890424 MOV DWORD PTR SS:[ESP],EAX 002511BF E8 EC8A0200 CALL 002511C4 83EC 08 SUB ESP,8 002511C7 89C2 MOV EDX,EAX 002511C9 85D2 TEST EDX,EDX 002511CB 74 09 JE SHORT liblcms-.002511D6 002511CD C70424 90AB2700 MOV DWORD PTR SS:[ESP],liblcms-.0027AB90 002511D4 FFD2 CALL EDX 002511D6 C9 LEAVE 002511D7 C3 RETN Here is a stack trace at the exception time: 0022F9D8 00251193 RETURN to liblcms-.00251193 from 8FC90000 0022F9DC 0027E500 liblcms-.0027E500 0022F9E0 0027F020 liblcms-.0027F020 0022F9E4 /0022FA04 0022F9E8 |0025125E RETURN to liblcms-.0025125E from liblcms-.00251170 0022F9EC |01220000 0022F9F0 |40000060 0022F9F4 |00000080 0022F9F8 |0022FAF4 0022F9FC |00000001 0022FA00 |00000001 0022FA04 ]0022FA24 0022FA08 |002510E1 RETURN to liblcms-.002510E1 from liblcms-.00251230 0022FA0C |00000080 0022FA10 |0022FA38 0022FA14 |012443D8 0022FA18 |0022FA3C 0022FA1C |00000001 0022FA20 |0022FA38 0022FA24 ]0022FA44 0022FA28 |76F413B4 RETURN to ntdll.76F413B4 0022FA2C |00250000 liblcms-.00250000 0022FA30 |00000001 0022FA34 |0022FD24 0022FA38 |00000001 0022FA3C |0022FAF4 0022FA40 |012443D8 0022FA44 ]0022FB3C 0022FA48 |76F2909B RETURN to ntdll.76F2909B from ntdll.76F413A0 0022FA4C |00251060 liblcms-. 0022FA50 |00250000 liblcms-.00250000 0022FA54 |00000001 0022FA58 |0022FD24 0022FA5C |76E66011 0022FA60 |00000000 0022FA64 |76F4BEC4 ASCII "LdrpInitializeProcess" 0022FA68 |7FFD9000 0022FA6C |0031D84D libMag_2.0031D84D 0022FA70 |FFFFFFFE 0022FA74 |76F29A03 RETURN to ntdll.76F29A03 from ntdll.76F4A15D 0022FA78 |76F29D29 RETURN to ntdll.76F29D29 from ntdll.76F298F6 0022FA7C |01249C08 0022FA80 |012420E0 0022FA84 |01089348 inkscape.01089348 0022FA88 |010A9E58 ASCII "libpoppler-5.dll" 0022FA8C |00000001 0022FA90 |76F64CB0 RETURN to ntdll.76F64CB0 0022FA94 |76F27E1B RETURN to ntdll.76F27E1B from ntdll.ZwQueryInformationProcess 0022FA98 |FFFFFFFF 0022FA9C |00000025 0022FAA0 |0022FAB8 0022FAA4 |00000030 0022FAA8 |00000000 0022FAAC |00000000 0022FAB0 |76F4BEC4 ASCII "LdrpInitializeProcess" 0022FAB4 |7FFD9000 0022FAB8 |00401110 inkscape. 0022FABC |00000000 0022FAC0 |00200000 0022FAC4 |00001000 0022FAC8 |00000002 0022FACC |00040000 0022FAD0 |00000024 0022FAD4 |00000001 0022FAD8 |00000000 0022FADC |00000000 0022FAE0 |00000030 0022FAE4 |FFFFFFFF 0022FAE8 |FFFFFFFF 0022FAEC |76F2907A RETURN to ntdll.76F2907A from ntdll.RtlActivateActivationContextUnsafeFast And here is my executable modules table. You can see that no dll exists around that address. Base Size Entry Name File version Path 00250000 0003C000 00251060 liblcms- C:\Apps\Inkscape\liblcms-1.dll 00290000 000E7000 002910C0 libMag_2 C:\Apps\Inkscape\libMagickWand-3.dll 00380000 0007A000 00381060 libgio-2 C:\Apps\Inkscape\libgio-2.0-0.dll 00400000 00CF5000 00401110 inkscape 0.48+devel C:\Apps\Inkscape\inkscape.exe 01100000 00012000 01101060 libpan_1 C:\Apps\Inkscape\libpangocairo-1.0-0.dll 01120000 00096000 01121060 libpan_2 1.26.1.0 C:\Apps\Inkscape\libpangoft2-1.0-0.dll 011C0000 0002A000 011DC88F libxslt C:\Apps\Inkscape\libxslt.dll 016C0000 003C9000 016C1060 libgtk-w 2.16.6.0 C:\Apps\Inkscape\libgtk-win32-2.0-0.dll 01A90000 00264000 01A910C0 libgtkmm C:\Apps\Inkscape\libgtkmm-2.4-1.dll 01D00000 001B1000 01D010C0 libpop_1 C:\Apps\Inkscape\libpoppler-5.dll 01EC0000 000DA000 01ECD0B7 iconv 1.9 C:\Apps\Inkscape\iconv.dll 01FA0000 00062000 01FA1412 mscms 6.0.6000.16386 ( C:\Windows\system32\mscms.dll 10000000 00012000 100092DA zlib1 1.2.2 C:\Apps\Inkscape\zlib1.dll 61180000 0000E000 61181000 pthreadG 2, 7, 0, 0 C:\Apps\Inkscape\pthreadGC2.dll 61A00000 0003C000 61A010C0 libpng14 C:\Apps\Inkscape\libpng14-14.dll 62140000 000A4000 621410C0 libcai_1 C:\Apps\Inkscape\libcairomm-1.0-1.dll 62940000 00020000 62941060 libatk-1 1.28.0.0 C:\Apps\Inkscape\libatk-1.0-0.dll 633C0000 00012000 633C1060 libpopt- C:\Apps\Inkscape\libpopt-0.dll 63600000 00017000 63601060 libgomp- C:\Apps\Inkscape\libgomp-1.dll 63A40000 00044000 63A41060 libgobje 2.22.3.0 C:\Apps\Inkscape\libgobject-2.0-0.dll 63CC0000 0007C000 63CC1060 freetype C:\Apps\Inkscape\freetype6.dll 64F80000 00041000 64F81060 libfontc C:\Apps\Inkscape\libfontconfig-1.dll 65340000 00038000 65341060 libgdk_p 2.18.5.0 C:\Apps\Inkscape\libgdk_pixbuf-2.0-0.dll 65580000 00049000 65581060 libpango 1.26.1.0 C:\Apps\Inkscape\libpango-1.0-0.dll 65C40000 0000E000 65C41060 libgthre 2.22.3.0 C:\Apps\Inkscape\libgthread-2.0-0.dll 664C0000 000D4000 664C10C0 libglibm C:\Apps\Inkscape\libglibmm-2.4-1.dll 66600000 0005D000 66601060 libtiff- C:\Apps\Inkscape\libtiff-3.dll 66A00000 0002B000 66A010C0 libopenj C:\Apps\Inkscape\libopenjpeg-2.dll 68280000 00190000 68281060 libwpg-0 0.1.0.0 C:\Apps\Inkscape\libwpg-0.1.dll 68440000 00017000 68441060 bzip2 1.0.5.3001 C:\Apps\Inkscape\bzip2.dll 685C0000 000F0000 685C1060 libglib- 2.22.3.0 C:\Apps\Inkscape\libglib-2.0-0.dll 68900000 0003B000 68901060 libjpeg- C:\Apps\Inkscape\libjpeg-7.dll 68DC0000 000F7000 68DC10C0 libcairo C:\Apps\Inkscape\libcairo-2.dll 68F40000 00023000 68F410C0 libexpat C:\Apps\Inkscape\libexpat-1.dll 69000000 00017000 69001000 intl 0.17 C:\Apps\Inkscape\intl.dll 695C0000 00075000 695C10C0 libMagic C:\Apps\Inkscape\libMagick++-3.dll 69C80000 00038000 69C81060 libpng12 C:\Apps\Inkscape\libpng12-0.dll 6A140000 00053000 6A1410C0 libgdkmm C:\Apps\Inkscape\libgdkmm-2.4-1.dll 6AA00000 0008F000 6AA010C0 libsigc- C:\Apps\Inkscape\libsigc-2.0-0.dll 6AC00000 00114000 6AC010C0 libxml2 C:\Apps\Inkscape\libxml2.dll 6B280000 00018000 6B281060 libpan_3 1.26.1.0 C:\Apps\Inkscape\libpangowin32-1.0-0.dll 6B780000 00078000 6B7810C0 libgiomm C:\Apps\Inkscape\libgiomm-2.4-1.dll 6C340000 000A9000 6C341060 libgdk-w 2.16.6.0 C:\Apps\Inkscape\libgdk-win32-2.0-0.dll 6CA00000 00102000 6CA01060 libwpg-s 0.1.0.0 C:\Apps\Inkscape\libwpg-stream-0.1.dll 6D440000 004E7000 6D4410C0 libMag_1 C:\Apps\Inkscape\libMagickCore-3.dll 6DD00000 0000E000 6DD01060 libgmodu 2.22.3.0 C:\Apps\Inkscape\libgmodule-2.0-0.dll 6E980000 0004D000 6E9810C0 libatkmm C:\Apps\Inkscape\libatkmm-1.6-1.dll 6EAC0000 0003C000 6EAC10C0 libpan_4 C:\Apps\Inkscape\libpangomm-1.4-1.dll 6F3C0000 0003C000 6F3C10C0 libpoppl C:\Apps\Inkscape\libpoppler-glib-4.dll 6FBC0000 0000C000 6FBC10C0 mingwm10 C:\Apps\Inkscape\mingwm10.dll 705F0000 00007000 705F1150 WSOCK32 6.0.6000.16386 ( C:\Windows\system32\WSOCK32.DLL 73580000 00042000 735A48EF WINSPOOL 6.0.6001.18000 ( C:\Windows\system32\WINSPOOL.DRV 74510000 0019E000 74543681 COMCTL32 6.10 (longhorn_r C:\Windows\WinSxS\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.6002.18305_none_5cb72f2a088b0ed3\COMCTL32.DLL 747D0000 00005000 747D11EE MSIMG32 6.0.6000.16386 ( C:\Windows\system32\MSIMG32.DLL 75120000 0002C000 75123EC1 DNSAPI 6.0.6000.16386 ( C:\Windows\system32\DNSAPI.DLL 75430000 00014000 75431235 Secur32 6.0.6002.18051 ( C:\Windows\system32\Secur32.dll 75450000 0001E000 7545152D USERENV 6.0.6000.16386 ( C:\Windows\system32\USERENV.dll 755A0000 0001E000 755A1378 IMM32 6.0.6002.18005 ( C:\Windows\system32\IMM32.DLL 755C0000 0002D000 755C1434 WS2_32 6.0.6000.16386 ( C:\Windows\system32\WS2_32.dll 755F0000 000C8000 755F169E MSCTF 6.0.6000.16386 ( C:\Windows\system32\MSCTF.dll 756C0000 000DC000 7570B7F5 kernel32 6.0.6001.18000 ( C:\Windows\system32\kernel32.dll 75960000 00145000 759B9558 OLE32 6.0.6000.16386 ( C:\Windows\system32\OLE32.dll 75AB0000 000C6000 75AF0CC1 ADVAPI32 6.0.6002.18005 ( C:\Windows\system32\ADVAPI32.dll 75B80000 000C3000 75BD02EB RPCRT4 6.0.6001.18000 ( C:\Windows\system32\RPCRT4.dll 75CD0000 00006000 75CD16B8 NSI 6.0.6001.18000 ( C:\Windows\system32\NSI.dll 75D70000 000AA000 75D79FAE msvcrt 7.0.6002.18005 ( C:\Windows\system32\msvcrt.dll 75E30000 00059000 75E4BA35 SHLWAPI 6.0.6000.16386 ( C:\Windows\system32\SHLWAPI.dll 75F90000 0004B000 75F9F12A GDI32 6.0.6002.18005 ( C:\Windows\system32\GDI32.dll 76170000 00073000 76171AC2 COMDLG32 6.0.6000.16386 ( C:\Windows\system32\COMDLG32.DLL 761F0000 00B11000 762690FD SHELL32 6.0.6001.18000 ( C:\Windows\system32\SHELL32.DLL 76F00000 00128000 ntdll 6.0.6001.18000 ( C:\Windows\system32\ntdll.dll 77030000 0009D000 77047A1D USER32 6.0.6001.18000 ( C:\Windows\system32\USER32.dll 770D0000 0008D000 770D3F45 OLEAUT32 6.0.6002.18005 C:\Windows\system32\OLEAUT32.dll