Comment 3 for bug 403988

That's perfectly acceptable to me, although where to put that (in ~/.bash_profile or ~/.profile for most users) will not be obvious to everyone.
If --force-nesting isn't passed, put a warning that an option is necessary for nesting, and maybe add a tip that people should use byobu-config to set up screen bindings with a different escape key on the remote host. Different escape keys are quite comfortable imho.